TABLE 2.
Cox proportional hazards regression models of various prognostic parameters in patients with GBM in TCGA.
| Characteristic | Non-adjusted model | Adjusted I model | Adjusted II model | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
| Age | 1.03 (1.01–1.04) | <0.001 | 1.02 (1.01–1.03) | 0.004 | 1.02 (1.0–1.03) | 0.008 |
| Gender | 0.96 (0.66–1.4) | 0.836 | — | — | 1.13 (0.75–1.71) | 0.562 |
| IDH status | 0.38 (0.16–0.94) | 0.036 | — | — | 0.72 (0.28–1.84) | 0.489 |
| Radiotherapy | 0.42 (0.26–0.67) | <0.001 | 0.37 (0.23–0.6) | <0.001 | 0.36 (0.18–0.75) | 0.006 |
| Chemotherapy | 0.57 (0.38–0.84) | 0.005 | — | — | 1.0 (0.53–1.88) | 0.997 |
| RCN1 | 1.71 (1.21–2.42) | 0.002 | 1.69 (1.16–2.46) | 0.007 | 1.67 (1.13–2.45) | 0.009 |
Adjusted I model: Factors including age, radiotherapy for adjustment, Adjusted II model: Factors including age, gender, IDH, radiotherapy and chemotherapy for adjustment. HR: hazard ratio, CI: confidence interval.