TABLE 3.
Subgroup analysis of the associations between OS and RCN1 of patients with GBM in TCGA.
| Covariates | Total (N = 153) | RCN1 | RCN1 a | ||
|---|---|---|---|---|---|
| HR (95% CI) | P for interaction | HR (95%CI) | P for interaction | ||
| Age | — | — | 0.2553 | — | — |
| <60 y | 72 | 2.02 (1.24–3.29) c | — | — | — |
| >=60 y | 81 | 1.36 (0.84–2.21) | — | — | — |
| Total | 153 | 1.66 (1.16–2.36) c | — | — | — |
| Gender | — | — | 0.8929 | — | 0.7652 |
| Male | 54 | 1.67 (0.98–2.83) | — | 1.83 (0.96–3.51) | — |
| Female | 99 | 1.75 (1.11–2.75) b | — | 1.62 (1.00–2.63) | — |
| Total | 153 | 1.71 (1.21–2.42) c | — | 1.69 (1.15–2.50) c | — |
| Radiotherapy | — | — | 0.6713 | — | — |
| No | 23 | 2.70 (0.50–14.62) | — | — | — |
| Yes | 130 | 1.86 (1.28–2.70) c | — | — | — |
| Total | 153 | 1.89 (1.31–2.73) d | — | — | — |
| Chemotherapy | — | — | 0.0019 | — | 0.0118 |
| No | 41 | 0.62 (0.29–1.33) | — | 0.81 (0.38–1.73) | — |
| Yes | 112 | 2.33 (1.53–3.53) d | — | 2.55 (1.63–3.98) d | — |
| Total | 153 | 1.66 (1.17–2.34) c | — | 1.91 (1.30–2.80) c | — |
a
Covariates were adjusted as in Adjusted I model (Table 2). HR (95% CI) were derived from Cox proportional hazards regression models.
b
P < 0.05.
c
< 0.01.
d
P < 0.001. HR: hazard ratio, CI: confidence interval.