Table 1.
Thalamocortical connectivity after administration of psychedelics.
| References | N | Age | Sex | Psychedelic | Seed | iFC | ROI(s) | P -value |
|---|---|---|---|---|---|---|---|---|
| Carhart-Harris et al. (79) | 15 | 32 ± 8.9 | 2 F | Psilocybin | Bilateral thalamus | – | DMN | 0.1 |
| Bilateral thalamus | ↑ | TPN | 0.03 | |||||
| Tagliazucchi et al. (80) | 15 | 32 ± 8.9 | Psilocybin | Bilateral thalamus | ↑ | ROIs covering sensorimotor, auditory, and visual cortices | <0.05, FDR | |
| 15 (of 20) | 30.9 ± 7.8 | 4 F | LSD | Bilateral thalamus | ↑ | ROIs covering sensorimotor, auditory, and visual cortices | <0.05, FDR | |
| Muller et al. (27) | 20 | 32.4 ± 10.9 | 10 F | LSD | Left thalamus | ↑ | 104 out of 130 ROIs covering the whole brain | <0.05, FDR |
| Right thalamus | ↑ | 104 out of 130 ROIs covering the whole brain | <0.05, FDR | |||||
| Bilateral thalamus | ↑ | Voxels covering sensorimotor and visual cortices | <0.05, FDR | |||||
| Preller et al. (28)* | 24 | 25 ± 3.60 | 5 F | LSD | Bilateral thalamus | ↑ | Grayordinates covering sensorimotor areas | <0.05, FWE |
| Bershad et al. (81) | 20 | 25 ± 4 | 10 F | LSD microdose | Bilateral thalamus | – | Cerebral cortex | – |
| Bilateral thalamus | ↑ | Cerebellum | <0.05, FDR |
Studies investigating effects of psychedelics on thalamocortical functional connectivity with seed-based correlation analysis, using the thalamus as seed. Of note, for psilocybin, Tagliazucchi et al. (80) reanalyzed the subjects from Carhart-Harris et al. (79). Hyperconnectivity is depicted by arrows pointing upwards (↑).
*
Depicts studies controlling for global signal regression in their analysis. N, number of participants; ROIs, regions of interest; F, female; FDR, false discovery rate; FWE, family-wise error; DMN, default mode network; TPN, task-positive network.