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. 2021 Oct 13;12:748718. doi: 10.3389/fmicb.2021.748718

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Copyright © 2021 Vasina, Antonova, Grigoriev, Yakimakha, Lendel, Nikiforova, Pochtovyi, Remizov, Usachev, Shevlyagina, Zhukhovitsky, Fursov, Potapov, Vorobev, Aleshkin, Laishevtsev, Makarov, Yudin, Tkachuk and Gushchin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of endolysins on the normal bacterial flora. (A) In vitro activity of LysAm24, LysECD7, LysAp22, and LysSi3 against Bifidobacterium spp. and Lactobacillus spp. strains. Activity spectra were assessed at 100-μg/ml endolysin concentration after 30-min incubation with bacterial suspension in a liquid medium. (B) Intestine microflora changes in mice under endolysin administration compared to control buffer (Tris–HCl) injections on the seventh day of experiment. Blue and red taxa indicate Gram-positive and Gram-negative bacteria correspondingly.