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. 2021 Oct 13;12:748718. doi: 10.3389/fmicb.2021.748718

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Copyright © 2021 Vasina, Antonova, Grigoriev, Yakimakha, Lendel, Nikiforova, Pochtovyi, Remizov, Usachev, Shevlyagina, Zhukhovitsky, Fursov, Potapov, Vorobev, Aleshkin, Laishevtsev, Makarov, Yudin, Tkachuk and Gushchin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Burn wound model of Wistar rats infected with the P. aeruginosa Ts 38-16 strain and epicutaneously treated with control buffer or 2,500-μg/ml endolysin solutions. (A) Count of culturable bacteria in the wound swabs of the infected areas. Significant differences are shown as p values; otherwise, no statistical difference was found (two-way ANOVA with the Sidak multiple-comparison test). Spleen (B) and dermal graft (C) microbial contamination (CFU/organ) on the seventh day of the experiment are shown. Significant differences are shown as p values; otherwise, no statistical difference was found (Mann–Whitney test). The resulting CFU/mL, CFU/graft, or CFU/organ values from each animal are plotted as individual points. Data are shown as mean±SEM.