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. 2021 Oct 13;12:728823. doi: 10.3389/fmicb.2021.728823

FIGURE 2.

FIGURE 2

Meta-analysis identifies a core set of gut microbes strongly associated with NAFLD. (A) Meta-analysis significance of gut microbial species derived from blocked Wilcoxon tests is given by the bar height (FDR = 0.05). Bars of a core of highly significant species (meta-analysis FDR = 1 × 10– 3) were colored as dark gray. (B) Species-level significance, as calculated with a blocked two-sided Wilcoxon test (FDR P value), and the generalized fold change within individual stages are displayed as heatmaps in gray and in color, respectively. Species are ordered by meta-analysis significance and direction of change. NAFL, non-alcoholic fatty liver; NASH, non-alcoholic steatohepatitis. (C) Association strength is quantified by the AUROC across individual stages (color-coded diamonds), and the 95% confidence intervals are indicated by the gray lines. Order-level taxonomic information is color-coded above the species names.