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. 2021 Oct 18;22(6):839. doi: 10.3892/ol.2021.13100

Figure 3.

Figure 3.

Association between circRNA-FOXO3 and miR-543 in NSCLC. (A) RT-qPCR analysis of circRNA-FOXO3 in NSCLC tissues and corresponding normal tissues. (B) Relative expression levels of miR-543 in NSCLC tissues and non-tumor tissues. (C) A negative correlation between circRNA-FOXO3 and miR-543 expression in specimens from patients with NSCLC was identified using Spearman's correlation analysis. (D) Expression levels of miR-543 in 16HBE cells and NSCLC cell lines (NCI-H1250, NCI-H1299, A549 and SK-MES-1) were determined by RT-qPCR. (E) Relative expression levels of miR-543 in H1975 and H1975/DDP cells. (F) Relative expression levels of miR-543 in H1975/DDP cells transfected with miR-543 or miR-NC. (G) Relative expression of miR-543 in H1975/DDP cells transfected with anti-miR-543 mimics or anti-miR-NC. Cell proliferation following treatment with different concentrations of DDP in H1975/DDP cells transfected with (H) anti-miR-543 or anti-miR-NC, or (I) miR-543 mimics or miR-NC. *P<0.05. circRNA, circular RNA; DDP, cisplatin; miR/miRNA, microRNA; NC, negative control; NSCLC, non-small cell lung cancer; RT-qPCR, reverse transcription-quantitative PCR.