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. 2021 Oct 18;22(6):839. doi: 10.3892/ol.2021.13100

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — circRNA-FOXO3 regulates glycolysis and DDP sensitivity in non-small cell lung cancer cells by sponging miR-543. (A) A lactic acid assay was performed to examine lactate production of cells transfected with circRNA vectors and/or miR-543 mimics. (B) A glucose uptake colorimetric assay was performed to examine glucose consumption of A549 cells transfected with circRNA vectors and/or miR-543 mimics. (C) A CCK-8 assay was performed to measure A549 cell proliferation following treatment with a series of doses of DDP. (D) Relative glucose consumption and (E) lactate production of H1975/DDP cells transfected with circRNA vectors and/or miR-543 mimics. (F) A CCK-8 assay was used to determine H1975/DDP cell proliferation following treatment with a series of doses of DDP following transfection as indicated. *P<0.05. CCK-8, Cell Counting Kit-8; circRNA, circular RNA; DDP, cisplatin; miR/miRNA, microRNA; NC, negative control.