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Connections between biological AD risk genes and drugs that were approved for other indications. Representative connections between AD biological genes (green); genes in PPIs (yellow); target drugs (blue); indication (orange). Grey lines indicate connections. Only IL1R1, BIRC5, B2M, and AURKB are directly connected to a biological gene-drug (anakinra, reserpine, berberine, copper, hesperidin); all other biological gene-drug connections are through the PPI network.
