Fig. 9.

ERC-ESICM 2021 algorithm for prognostication in PCABI. EEG electroencephalography, NSE neuron specific enolase, SSEP short-latency somatosensory evoked potentials, ROSC return of spontaneous circulation. ¹Major confounders may include sedation, neuromuscular blockade, hypothermia, severe hypotension, hypoglycaemia, sepsis, and metabolic and respiratory derangements. ²Use an automated pupillometer, when available, to assess pupillary light reflex. ³Suppressed background ± periodic discharges or burst suppression, according to ACNS. ⁴Increasing NSE values between 24 and 48 h or 24/48 h and 72 h further confirm a likely poor outcome. ⁵Defined as a continuous and generalised myoclonus persisting for 30 min or more. *Caution in case of discordant signs indicating a potentially good outcome (see text for details)