Table 1: Studies Included in the Systematic Review.

Authors	Kherad et al.[11]	Choudhury et al.[13]	Tyler et al.[14]	Göbel et al.[16]
Publication date	2016	2019	2020	2020
Centres	1	4	1	1
Prospective/retrospective	Prospective	Prospective	Prospective	Retrospective
Enrolment dates	January 2015 to July 2015	Not stated	September 2016 to October 2019	November 2013 to December 2018
Location	Berlin (Germany)	London (Canada), Stuttgart (Germany), Yokkaichi (Japan), Lisbon (Portugal)	London (UK)	Mainz (Germany)
Cohort overlap	Independent cohort	Update of Choudhury et al. 2018;[12] includes Schaufele et al. 2015[8] and partially includes Menezes et al. 2020[15]	Independent cohort	Update of Schulz et al. 2015[9]
Number of patients	18	130 (134)	25 (25)	323 (138)
Male (%)	67	62 (73)	72 (56)	73 (64)
Age (years) mean	46	56 (44)	48 (46)	56 (53)
Guide catheter used	7.5 Fr sheathless MP1	7.5 Fr sheathless (83%) most commonly MP1	6 Fr MP1	7.5 Fr Sheathless MP1
Bioptome used	Medizintechnik, Meiners	Several different devices	Cordis 5.5 Fr 104 cm	Medwork 180 cm
Success rate (% of patients with biopsy obtained)	100	99 (100)	88 (96)	99 (100)
Minimum number of specimens required	10	Not stated	3 (3)	Not stated
Mean number of specimens obtained	10	6.8 (6.1)	4 (5)	7 (7)
Blood transfusion (%)	0	0 (0)	4 (0)	0 (0)
Pericardial effusion (%)	0	3.1 (10)	8 (4)	11.1 (7.4)
Tamponade/drain (%)	0	0 (0)	4 (4)	0 (0)
VF (%)	0	0 (0)	0 (0)	0.3 (0)
CVA (%)	0	0 (0)	0 (0)	0.6 (0.7)
Crossover to RFA (%)	0	1.0	4 (4)	0.3
Mitral valve injury (%)	0	0 (0)	0 (0)	0 (0.7)
Death (%)	0	0 (0)	0 (0)	0 (0)

Three studies included cohorts of patients who underwent transfemoral LVEMB for comparison. Values for these cohorts are given in brackets. CVA = cerebrovascular accident; RFA = right femoral access.