Figure 3.

The proportion of ITC‐25 detected in peripheral blood T‐cell subsets, and the productive clonalities of CD4 and CD8 subsets in pre‐therapy blood. Pre‐therapy peripheral blood T cells were FACS sorted into seven subsets, and the clonotypes were matched with ITC from (unsorted) DLBCL diagnostic biopsies. (a) The proportion of the most abundant 25 intratumoral clonotypes (ITC‐25) detected in various peripheral blood T‐cell subsets are shown. The majority of ITC 25 were seen in CD8⁺ compartments in peripheral blood. (b) The productive clonalities of circulating CD4⁺ and CD8⁺ T cells. Here, the productive clonality of CD8⁺ T cells was significantly higher than that of CD4⁺ T cells.