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. Author manuscript; available in PMC: 2021 Nov 20.
Published in final edited form as: ACS Chem Biol. 2020 Oct 12;15(11):2854–2859. doi: 10.1021/acschembio.0c00494

Figure 4.

Figure 4.

nTRD22 mitigates motor defects in a Drosophila model of ALS overexpressing TDP-43. (A) Principle of the sensitized version of the negative geotaxis assay.22 Flies are transferred without anesthesia to a wax-sealed glass graduated cylinder. Flies are tapped to the bottom, and their subsequent climbing activity is quantified for 2 min. The number of flies crossing the target line (red) at each time point chosen (every 10 s) is recorded. (B) Fly food supplemented with nTRD22 (50 μM) resulted in increased motor performance, compared to naïve or DMSO-treated flies (n = 60, (****) p < 0.0001, two-way ANOVA).