Table 1.
Baseline demographic and clinicopathologic features of patients in this study.
| Patient characteristics | Negative CYP1B1a expression, n (%) | Low CYP1B1 expression, n (%) | Moderate CYP1B1 expression, n (%) | High CYP1B1 expression, n (%) | P value | ||
| Age (years) | .70 | ||||||
|
|
<50 (n=69) | 8 (12) | 11 (16) | 12 (17) | 38 (55) |
|
|
|
|
≥50 (n=41) | 9 (22) | 9 (22) | 6 (15) | 17 (41) |
|
|
| Pathology subtype | .01 | ||||||
|
|
Squamous cell carcinoma (n=95) | 9 (10) | 18 (19) | 18 (19) | 50 (53) |
|
|
|
|
Adenocarcinoma (n=3) | 0 (0) | 0 (0) | 0 (0) | 3 (100) |
|
|
|
|
Endometrioid adenocarcinoma (n=2) | 0 (0) | 0 (0) | 0 (0) | 2 (100) |
|
|
|
|
Normal (n=10) | 8 (80) | 2 (20) | 0 (0) | 0 (0) |
|
|
| Histological grade | .03 | ||||||
|
|
I (n=9) | 1 (6) | 0 (0) | 1 (6) | 7 (13) |
|
|
|
|
II (n=27) | 3 (18) | 9 (45) | 4 (22) | 11 (20) |
|
|
|
|
III (n=64) | 5 (29) | 9 (45) | 13 (72) | 37 (67) |
|
|
| Histological stage | .01 | ||||||
|
|
I (n=56) | 3 (17) | 10 (50) | 11 (61) | 32 (58) |
|
|
|
|
II (n=38) | 6 (35) | 5 (25) | 6 (33) | 21 (38) |
|
|
|
|
III (n=6) | 0 (0) | 3 (15) | 1 (6) | 2 (4) |
|
|
| Tumor node metastasis histological stage | .03 | ||||||
|
|
T1 (n=59) | 3 (18) | 11 (55) | 12 (67) | 33 (60) |
|
|
|
|
T2 (n=38) | 6 (35) | 5 (25) | 6 (33) | 21 (38) |
|
|
|
|
T3 (n=3) | 0 (0) | 2 (10) | 0 (0) | 1 (2) |
|
|
| Lymph node metastasis | .01 | ||||||
|
|
Negative (n=95) | 9 (53) | 5 (75) | 31 (33) | 54 (98) |
|
|
|
|
Positive (n=5) | 0 (0) | 3 (15) | 1 (6) | 1 (2) |
|
|
| Distant metastasis | .13 | ||||||
|
|
Negative (n=100) | 9 (100) | 18 (100) | 18 (100) | 55 (100) |
|
|
|
|
Positive (n=0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Human papilloma virus 16/18 status | .04 | ||||||
|
|
Low (n=32) | 10 (31) | 3 (9) | 4 (13) | 15 (47) |
|
|
|
|
Medium (n=46) | 3 (7) | 7 (15) | 7 (15) | 29 (63) |
|
|
|
|
High (n=32) | 1 (3) | 3 (9) | 5 (16) | 23 (72) |
|
|
| Ki67 status | .75 | ||||||
|
|
Low (n=56) | 12 (71) | 12 (60) | 8 (44) | 24 (44) |
|
|
|
|
Moderate (n=36) | 5 (29) | 5 (25) | 7 (39) | 19 (35) |
|
|
|
|
High (n=18) | 0 (0) | 3 (15) | 3 (17) | 12 (22) |
|
|
aCYP1B1: cytochrome P450 1B1.