Table II.
Rates of dMMR in relation to clinicopathological findings of patients with CRC.
| Patient characteristics | pMMR, n (%) | dMMR, n (%) | P-value |
|---|---|---|---|
| Total | 427 (92.6) | 34 (7.4) | |
| Age, years | N/Aa | ||
| ≤39 | 6 (85.7) | 1 (16.7) | |
| 40-49 | 24 (92.3) | 2 (7.7) | |
| 50-59 | 64 (98.5) | 1 (1.5) | |
| 60-69 | 122 (91.7) | 11 (8.3) | |
| ≥70 | 211 (91.7) | 19 (8.3) | |
| Personal history of CRC and/or other LS-related cancer | 0.12 | ||
| Present | 78 (88.6) | 10 (11.4) | |
| Absent | 349 (93.6) | 24 (6.4) | |
| Family history of CRC and/or other LS-related cancer | 0.48 | ||
| Present | 186 (91.6) | 17 (8.4) | |
| Absent | 241 (93.4) | 17 (6.6) | |
| Mode of treatment | 0.84 | ||
| Endoscopic resection | 114 (93.4) | 8 (6.6) | |
| Surgery | 313 (92.3) | 26 (7.7) | |
| Tumor location | <0.01 | ||
| Right | 130 (83.3) | 26 (16.7) | |
| Left | 297 (97.4) | 8 (2.6) | |
| Tumor histology | <0.01 | ||
| High-grade adenocarcinoma/mucinous/other | 41 (78.8) | 11 (21.2) | |
| Low-grade adenocarcinoma | 386 (94.4) | 23 (5.6) | |
| UICC stage | 0.13 | ||
| 0 | 84 (94.4) | 5 (5.6) | |
| I/II | 188 (90.0) | 21 (10.0) | |
| III/IV | 155 (95.1) | 8 (4.9) |
aStatistical analysis was not performed because expected values were <5 in >20% of the cells. dMMR, deficient mismatch repair; pMMR, proficient mismatch repair; CRC, colorectal cancer; LS, Lynch syndrome; UICC, Union for International Cancer Control; N/A, not applicable.