Table I.
Basic clinical and pathological features of the patients from the two cohorts.
| Parameter | Primary cohort (n=96) | Validation cohort (n=153) | P-value |
|---|---|---|---|
| Age, years | 0.191 | ||
| Median | 62.5 | 66 | |
| Range | 24-90 | 22-95 | |
| Sex | 0.240 | ||
| Male | 63 (65.6) | 89 (58.2) | |
| Female | 33 (34.4) | 64 (41.8) | |
| Tumor location | 0.108 | ||
| Colon | 62 (64.6) | 83 (54.2) | |
| Rectum | 34 (35.4) | 70 (45.8) | |
| Histological type | 0.270 | ||
| Adenocarcinoma | 94 (97.9) | 144 (94.1) | |
| Othera | 2 (2.1) | 9 (5.9) | |
| Vascular invasion | 0.505 | ||
| Yes | 7 (7.3) | 8 (5.2) | |
| No | 89 (92.7) | 145 (94.8) | |
| Grade | 0.705 | ||
| G1 | 5 (5.2) | 5 (3.3) | |
| G2 | 74 (77.1) | 123 (80.4) | |
| G3 | 17 (17.7) | 25 (16.3) | |
| T stage | 0.866 | ||
| T1+T2 | 9 (9.4) | 12 (7.8) | |
| T3 | 76 (79.2) | 121 (79.1) | |
| T4 | 11 (11.5) | 20 (13.1) | |
| N stage | 0.976 | ||
| N0 | 58 (60.4) | 91 (59.5) | |
| N1 | 27 (28.1) | 45 (29.4) | |
| N2 | 11 (11.5) | 17 (11.1) | |
| TNM stage | 0.246 | ||
| IA+IB | 7 (7.3) | 12 (7.8) | |
| IIA+IIB | 45 (46.9) | 76 (49.7) | |
| IIIA+IIIB | 35 (36.5) | 60 (39.2) | |
| IVA | 9 (9.3) | 5 (3.3) |
aSignet-ring cell carcinoma and mucinous adenocarcinoma. Values are expressed as n (%) unless otherwise specified.