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Potency of MDPV inhibiting DA-induced Ca2+ signals at dDAT mutants.
| Construct | pIC50 ± SEM(M) | IC50 (nM) | # cells analyzed |
|---|---|---|---|
| P323V | 5.01 ± 0.03 | 9,694 | 272 |
| A117S | 5.08 ± 0.04 | 8,391 | 336 |
| F318C | 5.08 ± 0.02 | 8,237 | 369 |
| D121G | 5.33 ± 0.04 | 4,646 | 297 |
| A117S/D121G | 5.66 ± 0.04 | 2,209 | 434 |
| A117S/D121G/P323V | 5.93 ± 0.02 | 1,184 | 747 |
| A117S/D121G/P323V/F318C | 6.60 ± 0.03 | 253 | 459 |
