Table 2.
Potency of MDPV and analogs inhibiting DA-induced Ca2+ signals at the indicated transporters.
| Construct, pIC50 ± SEM (M), (IC50 nM; # cells analyzed) | ||||
|---|---|---|---|---|
| wt dDAT | triple dDAT mut | quad dDAT mut | wt hDAT | |
| MDPV | 4.56 ± 0.02 (27,350; 437) | 5.92 ± 0.02 (1,207; 438) | 6.60 ± 0.04 (251; 396) | 7.47 ± 0.01 (34; 459) |
| α-PVP | 4.68 ± 0.03 (20,710; 699) | 5.82 ± 0.03 (1,531; 599) | 5.96 ± 0.03 (1,094; 481) | 7.29 ± 0.01 (51; 569) |
| MDPPP | Inactive (>>30,000; 246) | 4.80 ± 0.02 (15,960; 551) | 4.89 ± 0.01 (12,950; 507) | 5.47 ± 0.02 (3,418; 639) |