Table 1. Experimentally Determined Rate Constants of the Epimerization and Half-Lives of Native F430 and 12,13-Diepi-F430.

	pH 5			pH 7			pH 9
Experimental temperature (°C)	knative	Standard (Std.) error	t1/2 (h)	knative	Std. error	t1/2 (h)	knative	Std. error	t1/2 (h)
60	4.61 × 10–02	3.80 × 10–03	15	4.54 × 10–02	4.51 × 10–03	15	6.19 × 10–02	2.13 × 10–03	11
34	1.27 × 10–02	4.07 × 10–04	55	5.95 × 10–03	2.53 × 10–04	116	9.02 × 10–03	4.95 × 10–04	77
15	1.00 × 10–03	1.86 × 10–04	693	4.85 × 10–04	2.53 × 10–04	1429	4.52 × 10–04	1.62 × 10–04	1533
2	3.03 × 10–04		2291	9.49 × 10–05		7306	1.07 × 10–04		6464

Experimental temperature (°C)	kdiepi	Std. error	t1/2 (h)	kdiepi	Std. error	t1/2 (h)	kdiepi	Std. error	t1/2 (h)
60	2.65 × 10–02	2.82 × 10–03	26	1.22 × 10–02	1.20 × 10–03	57	2.69 × 10–02	8.52 × 10–04	26
34	1.04 × 10–02	7.07 × 10–04	67	2.20 × 10–03	2.51 × 10–04	315	3.70 × 10–03	7.74 × 10–04	187
15	1.07 × 10–03	2.20 × 10–04	648	3.77 × 10–04	2.59 × 10–04	1836	4.74 × 10–04	1.69 × 10–04	1463
2	4.73 × 10–04		1467	1.20 × 10–04		5791	1.25 × 10–04		5558

^aThe rate constants at 2 °C are calculated via extrapolation of the relationships between the reaction temperature and rate constant, as shown in Figure 3.