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. 2021 Sep 15;1(10):1527–1540. doi: 10.1021/jacsau.1c00308

Figure 2.

Figure 2

Sequestration of lipid II and concomitant pore formation by the lanthipeptide–lipid II complex, leading to bacterial cell lysis and death. This dual mechanism of action has been described for several lanthipeptides including mutacin-1140 and epidermin.28,31 However, other lanthipeptides such as mersacidin are currently believed to only partake in sequestration of lipid II without pore formation.32 Further investigation is required to identify other pore-forming lanthipeptides. A = l-alanine, a = d-alanine, K = lysine, E = glutamic acid, G = GlcNAc (N-acetylglucosamine), M = MurNAc (N-acetylmuramic acid), P = phospho group. Created with BioRender.com.