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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: J Thromb Haemost. 2021 Feb 10;19(4):1001–1017. doi: 10.1111/jth.15236

FIGURE 5.

FIGURE 5

Macrophage accumulation and fibrin deposition into atherosclerotic lesions in 14E11- and FXI-ASO-treated Ldlr−/− mice. (A-B) Cross-sections of aortic sinus were obtained and macrophage accumulation was determined by CD68 staining (red) together with nuclei (blue) in the atherogenesis model (A) and established atherosclerosis model (B). (C-D) Cross-sections of aortic sinus were obtained and fibrin deposition was determined by fibrin staining (red) together with nuclei (blue) in the atherogenesis model (C) and established atherosclerosis model (D). Area fraction was calculated as percent lesion area threshold positive after using a Phansalkar local autothreshold with radius of 5 px using Fiji software. Data were analyzed using Kruskal-Wallis with Dunn post hoc test. *p < .05. Scale bar = 200 μm