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. 2021 Oct 26;21:565. doi: 10.1186/s12935-021-02260-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — OSM-related cell infiltration and molecule expressions in tumor microenvironment. a OSM-related ESTIMATE score, immune score and stromal score in tumor microenvironments of the top3 cancer types (KICH, PCPG and GBM) via ESTIMATE algorithm. Spearman’s p values and partial correlation values are displayed. And density distribution of OSM levels, stromal scores, immune Scores, and ESTIMATE scores are also plotted. b Correlation analysis between OSM expression and the specific immune cell types in BLCA, BRCA, and CESC via TIMER algorithm. Dendritic cell, macrophage, neutrophil, B cell, CD4⁺ T cell, and CD8⁺ T cell are involved. Spearman’s p values and partial correlation values are displayed. c Correlation heatmap of OSM-related immune checkpoints across 33 cancer types in TCGA. d Correlation heatmap of OSM-related chemokines across 33 cancer types in TCGA. The colors in the bottom right corner of each grid represent Spearman’s correlation values. And the colors in the upper left corner of each grid represent Spearman’s p values. *p < 0.05, **p < 0.01, ***p < 0.001