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. 2021 Oct 26;21:565. doi: 10.1186/s12935-021-02260-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Correlation analysis between OSM expression and MMR gene, DNA methyltransferase gene expressions. a Heatmap of OSM-related five MMR gene co-expression (MLH1, MSH2, MSH6, PMS2, and EPCAM) of different cancers in TCGA. The colors in the bottom left corner of each grid represent Spearman’s correlation values. And the colors in the upper right corner of each grid represent Spearman’s p values. b Visualization of OSM-DNA methyltransferase gene co-expression. The colors of red, blue, green, and purple represent DNMT1, DNMT2, DNMT3A, and DNMT3B, respectively