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. 2021 Oct 26;21:565. doi: 10.1186/s12935-021-02260-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Main proteins and signaling pathways with regard to OSM-induced tumor progression. a PPI network of main OSM-binding proteins via STRING analysis. b Volcano plot shows the distribution of OSM-up-regulated and down-regulated genes. c Histogram of main OSM-up-regulated pathways in the OSM high expression group based on KEGG enrichment analysis. d Network plot to visualize the enriched pathways. The number of circles with identical colors represents the enrichment degree of each pathway. e Histogram of main OSM-down-regulated pathways in the OSM high expression group based on KEGG enrichment analysis. f Network plot to visualize the enriched pathways. g Enrichment plot of the main OSM-up-regulated and down-regulated pathways via GSEA analysis of GO gene sets. h Enrichment plot of the main OSM-up-regulated and down-regulated pathways via GSEA analysis of KEGG gene sets