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. 2021 Oct 26;21:565. doi: 10.1186/s12935-021-02260-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Role of OSM in migration, invasion and proneural-mesenchymal transition of glioblastoma cells. a The wound healing of glioblastoma cells using scratch assay. Scale bar, 50 μm. Magnification, 200×. b Statistical analysis of wound healing rates. c Invasive potential of glioblastoma cells in matrigel invasion assay. Scale bar, 50 μm. Magnification, 200×. d Statistical analysis of the number of cell counts in each field of view. e mRNA levels of mesenchymal signature genes in control and OSM-treated group. f mRNA levels of proneural signature genes in control and OSM-treated group. g Representative immunoblots showing levels of CD44, FN1, CHI3L1, CD24, DLL3 and OLIG2 in U251 cells. β-ACTIN was the loading control. h ChIP-seq analysis of the binding site of STAT3 to OSMR, LIFR and IL6R. i mRNA levels of OSM-related receptors (OSMR, LIFR and IL6R) in control and OSM-treated group. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001