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. 2021 Oct 26;16:109. doi: 10.1186/s13020-021-00521-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Analysis of the differential proteins (DPs) for the two classes of Syndromes. (A) The identified protein number in each group. (B) Coefficient of variation of proteins in Standard samples. The volcano plots of DPs between CCQS and HC group (C) or QSBS and HC group (D). (E) Overlaps between DPs of the two Syndromes. (F) Protein–protein interaction network for DPs of CCQS Syndrome. (G) Protein–protein interaction network for DPs of QSBS Syndrome. (H) KEGG pathways enriched with DPs and proteins in PPI networks for DPs of the two Syndromes. In F, G, Pink circles are common DPs of the two Syndromes, blue and orange circles are DPs specific for CCQS and QSBS Syndrome, respectively. Purple circles are proteins functionally associated with the DPs