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. 2021 Oct 26;16:109. doi: 10.1186/s13020-021-00521-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Analysis of the signature targets for the two classes of formulae. (A) Overlaps between the targets of the 3 formulae for CCQS. (B) Overlaps between the targets of the 3 formulae for QSBS. (C) Overlaps between the signature targets of the two classes of formulae. (D) Number of signature targets that overlapped with targets of FDA-approved CHD-related drugs, where black, green, orange, and blue text were drug categories for cardiovascular system (ATC ID:C), diabetes (ATC ID: A10), thrombotic events (ATC ID: B01), and obesity (ATC ID: A08), respectively. (E) Target-drug network between signature targets and FDA-approved CHD-related drugs. Pink cercles were common signatures for the two classes of formulae, while blue and orange circles were F1- and F2-specific signature targets, respectively. Diamond, triangle, V-type, and rectangle nodes were drugs for cardiovascular system, diabetes, ischemic stroke, and obesity, respectively