Table 4.
Disease clusters enriched with Syndrome-specific genes in the metabolite-gene networks
| Syndrome | Enrichment score/Rank | Disease Term | P value | Mapped genes |
|---|---|---|---|---|
| CCQS | 3.09/1 | Metabolic syndrome | 5.28E−05 | MMP1, PON1, ADIPOQ, HMOX1, F3 |
| Atherosclerosis, coronary | 0.001006 | MMP1, PON1, ADIPOQ, HMOX1 | ||
| Atherosclerosis | 0.010393 | MMP1, PON1, ADIPOQ, HMOX1 | ||
| QSBS | 2.58/1 | Hyperlipidemias | 7.44E−04 | SREBF1, APOA1, APOE |
| Hypercholesterolemia | 9.77E−04 | SREBF1, APOA1, APOE | ||
| Plasma HDL cholesterol (HDL-C) levels | 0.024904 | SREBF1, APOA1, APOE | ||
| 2.41/2 | Cerebrovascular disease; sickle cell anemia | 2.12E−04 | APOA1, APOE, ICAM1 | |
| Coronary Artery Disease | 0.001195 | APOA1, APOE, ICAM1 | ||
| Acute Coronary Syndrome | 0.002469 | APOA1, APOE, ICAM1 | ||
| Hepatitis C|Remission, Spontaneous | 0.005417 | APOA1, APOE, ICAM1 | ||
| Atherosclerosis, coronary | 0.010151 | APOA1, APOE, ICAM1 | ||
| Stroke | 0.100306 | APOA1, APOE, ICAM1 |
Genes of Italic characters are DPs