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Exposure to PM induces transcriptomic changes across the entire lung at 4-h post exposure. A UMAP plot of all vehicle-exposed cells compared to PM-exposed cells showing a conserved cellular heterogeneity during 4-h timepoint. B Volcano plot showing fold change of 210 differentially expressed genes (DEG) over vehicle-exposed that were FDR < 0.05. C KEGG pathway analysis illustrating an increase in Il17 signaling, Tnf signaling, toll-like receptor signaling, and P 53 signaling
