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. 2021 Oct 26;22:275. doi: 10.1186/s12931-021-01867-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Distinct T-cell populations (characterized in Fig. 3) show dysregulation across immunological pathways essential to eTh17 cell cytokine production. A Upregulated Th17 specific pathways associated with PM exposure in alpha–beta T cells. B Upregulated Th17 specific pathways associated with PM exposure in NK T cells. C Upregulated Th17 specific pathways associated with PM exposure in gamma–delta T cells. Significance was tested by Wilcoxon rank sum test with Bonferroni correction FDR < 0.05. Combined score is a combination of the p-value and z-score (calculated by using a modification to Fisher’s exact test) calculated by multiplying the two scores