Table 3.
Risk factors for aspirin HRPR
| Characteristics | Non-HRPR (n = 872) | HRPR (n = 130) | P Value |
|---|---|---|---|
| Age (y) | 57.0 [50.0–65.0] | 58.0 [50.8–66.0] | 0.545 |
| Male, n (%) | 632 (72.5) | 94 (72.3) | 0.968 |
| Smoking, n (%) | 428 (49.1) | 63 (48.5) | 0.895 |
| Alcohol intake, n (%) | 361 (41.4) | 52 (40.0) | 0.763 |
| Medical history, n (%) | |||
| History of stroke/TIA | 155 (17.8) | 35 (26.9) | 0.013 |
| Hypertension | 591 (67.8) | 87 (66.9) | 0.846 |
| Diabetes mellitus | 295 (33.8) | 43 (33.1) | 0.865 |
| Hyperlipidemia | 99 (11.4) | 13 (10.0) | 0.648 |
| Coronary heart disease | 77 (8.80) | 10 (7.70) | 0.667 |
| Laboratory data | |||
| Triglyceride (mmol/L) | 3.46 [2.81–4.18] | 3.84 [3.09–4.40] | 0.001 |
| Total cholesterol (mmol/L) | 1.23 [0.92–1.07] | 1.30 [1.02–1.88] | 0.141 |
| HDL-C (mmol/L) | 0.92 [0.79–1.07] | 0.92 [0.77–1.09] | 0.902 |
| LDL-C (mmol/L) | 2.08 [1.49–2.68] | 2.33 [1.80–3.00] | 0.001 |
| Creatinine (μmol/L) | 72.0 [62.0–85.0] | 73.0 [62.8–83.0] | 0.763 |
| eGFR (mL/min/1.73m2) | 94.4 [82.5–103] | 94.4[80.9–105] | 0.891 |
| Platelet count (×109/L) | 211 [177–251] | 221 [180–264] | 0.060 |
| PDW (fL) | 13.3 [11.8–15.0] | 13.3 [11.9–15.1] | 0.935 |
| P-LCR (%) | 33.0 [27.3–39.7] | 32.1 [27.0–38.3] | 0.593 |
| Fasting glucose (mmol/L) | 5.29 [4.84–6.29] | 5.55 [5.05–6.75] | 0.010 |
| HbA1c (%) | 5.80 [5.50–6.50] | 5.90 [5.60–6.80] | 0.297 |
| MA (mm) | 62.4 [58.7–66.0] | 63.6 [58.2–66.1] | 0.337 |
| TyG index quartiles | < 0.001 | ||
| Q1 (< 2.02) | 232 (26.6) | 18 (13.8) | |
| Q2 (2.02–2.27) | 221 (25.3) | 30 (23.1) | |
| Q3 (2.27–2.52) | 214 (24.5) | 37 (28.5) | |
| Q4 (≥2.52) | 205 (23.5) | 45 (34.6) | |
Data given as n (%) or median [interquartile range]
Abbreviations: TIA transient ischemic attack, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, eGFR glomerular filtration rate, PDW platelet distribution width, P-LCR platelet large cell ratio, HbAc1 glycosylated hemoglobin A1c, MA maximum amplitude, TyG index triglyceride glucose index, Q1–Q4 TyG index quartiles