Fig. 5.

ZIP10-ITGA10-p-AKT signaling is required for the maintenance of cisplatin resistance in vivo. a-c Photographed xenograft tumors (a), average tumor volume (b) and tumor weight (c) of 143B-NC, 143B-oeZIP10, 143B-oeZIP10 + 666–15 and 143B-oeZIP10 + GSK690693 xenografts treated with vehicle (Con) or cisplatin (Cis). Scale bar, 1 cm. N = 6 mice per group. d WB analysis was performed to detect target proteins, as indicated in xenograft tissues. e IHC staining analysis of ZIP10, ITGA10, p-AKT, Ki67 and C-caspase-3 in xenograft tissues. Scale bar, 20 μm. Data are means ± SEM; *P < 0.05, **P < 0.01