Table 1.
Evaluation of genotypic analysis for the prediction of resistance phenotypes for S. Typhi
Genotype resistance is classified as having one or more genetic marker/mutation.
|
Antibiotic |
MIC no.* |
Phenotype: susceptible |
Phenotype: resistant |
||
|---|---|---|---|---|---|
|
Genotype: resistant |
Genotype: susceptible |
Genotype: resistant |
Genotype: susceptible |
||
|
AMX |
1034 |
0 |
726 |
308 |
0 |
|
AMX-CL |
1034 |
0 |
726 |
308 |
0 |
|
CAZ |
1034 |
0 |
983 |
51 |
0 |
|
CRO |
1034 |
0 |
983 |
51 |
0 |
|
ETP |
1034 |
0 |
1034 |
0 |
0 |
|
GEN |
1034 |
0 |
1034 |
0 |
0 |
|
CIP |
1034 |
0 |
83 |
950 |
1 |
|
AZM |
1034 |
0 |
1034 |
0 |
0 |
|
TMP |
1034 |
1 |
704 |
328 |
1 |
|
FOS |
1013 |
0 |
1012 |
1 |
0 |
|
TET |
1034 |
0 |
1006 |
28 |
0 |
|
SXT |
1034 |
0 |
698 |
336 |
0 |
|
CHL |
1034 |
0 |
711 |
323 |
0 |
|
COL |
1034 |
0 |
1034 |
0 |
0 |
|
Total combinations |
14 455 |
– |
– |
– |
– |
AMX, Amoxicillin; AMX-CL, amoxicillin/clavulanic acid; CAZ, ceftazidime; CIP, ciprofloxacin; CRO, ceftriaxone; ETP, ertapenem; GEN, gentamicin; AZM, azithromycin; TMP, trimethoprim; FOS, fosfomycin; TET, tetracycline: SXT, trimethoprim/sulphonamide; CHL, chloramphenicol; COL, colistin. Numbers in bold relate to descrepancies between genotype and phenotype.
*The number of isolates that had phenotypic MIC testing.