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. Author manuscript; available in PMC: 2022 Sep 29.
Published in final edited form as: ACS Appl Mater Interfaces. 2021 Sep 14;13(38):45236–45243. doi: 10.1021/acsami.1c11620

Figure 1.

Figure 1.

Schematic of the sensing mechanism for the detection of trypsin. (A) Peptide-/protease-mediated gold nanoparticle growth and the effect of trypsin on the final nanoparticle morphology. The opaque blue background represents the growth solution. (B) Structure of the dithiol peptide GCKGCG and its subsequent cleavage by trypsin (PDB 1TRN) to produce two monothiol peptides, GCK and GCG. (C,D) Ligand-binding modes depicting the effective change in thiol concentration on the gold nanoparticle surface during growth without trypsin incubation (C) and with trypsin incubation (D).