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. 2021 Oct 26;21:564. doi: 10.1186/s12935-021-02251-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Hypomethylation of PLAU and its prognostic value in HNSCC. a PLAU was significantly hypomethylated in HNSCC tissues compared to the normal group. b PLAU methylation was negatively associated with PLAU expression. c No significant association was found between PLAU expression and DNMT1 (left) or DNMT3A (middle) levels. The positive correlation between PLAU expression and DNTM3B was significant (right). d Higher methylation of PLAU predicted a longer survival time compared to hypomethylation. e Lower methylation was correlated with higher clinical stage (above) and more aggressive metastasis (below). f PLAU methylation was lower in p53 mutant group than in the nonmutant group