Extended Data Fig. 5. Time-kill kinetics, post-antibiotic effect, and post-antibiotic sub-MIC effect data of iboxamycin (IBX) against susceptible strains.

a, Arrayed growth curves for three susceptible strains showing concentration effects on growth inhibition (time-kill), growth kinetics following exposure to antibiotic at 4×MIC (PAE), and growth kinetics under sub-MIC concentrations following exposure to antibiotic at 4×MIC (PA-SME). Points represent mean values from n = 2 biologically independent experiments. b, Tabulated PAE and PA-SME durations (determined as the difference in time required for bacterial counts to rise 10× between experimental and untreated control arms). Abbreviations: CLI, clindamycin; LNZ, linezolid.