Extended Data Fig. 4. Efficacy of iboxamycin (IBX) in mouse models of infection. Bacterial counts were quantified in the thighs of neutropenic mice infected with S. pyogenes ATCC 19615.
(a), S. aureus MRSA HAV017 (b), A. baumannii ATCC 19616 (c) or E. coli MDR HAV504 (d) treated with IBX, vehicle, or comparator antibiotic at the listed time points post-treatment. Data are mean ± s.d.; n = 8 thighs from 4 mice examined over 2 experiments, with the exception the sub-set of part c where mice received IBX via intravenous administration (n = 4 thighs from 2 mice examined over a single experiment). e, Mouse survival in an an S. pyogenes systemic infection model. Abbreviations: AZM, azithromycin; CLI, clindamycin; CPFX, ciprofloxacin; IP, intraperitoneal administration; IV, intravenous administration..