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Transmission electron micrograph of biopsy taken from patient 1. Showing coarsely granular bile and pericanalicular filamentous actin, indicated by arrow (A, original magnification ×2600). Biopsy from patient 2 showing relatively normal canaliculus and desmosome apparently detached from plasma membrane, indicated by arrow (B, original magnification ×9200). Biopsy from patient 5 showing unremarkable canaliculi and tight junctions (C, original magnification ×2600).
