TABLE 3.
Sleep disruption, vasomotor symptoms and heart palpitations, mood changes, headache and sore breasts, brain fog and dizziness: number reporting (n, %), frequency, bother and burden for women reporting symptoms by late reproductive stage (LRS) and menopausal transition+ groups (N = 1,436)
| Symptom (total N reporting) | Number reporting symptom (n = 1,436) | LRS number reporting (n = 945) | MT+ number reportinga (n = 491) | LRS frequency (modal category) | MT+ frequency (modal category)b | LRS bother rating M (SD) | MT+ bother ratingc M (SD) | LRS burden score M (SD) | MT+ burden scored M (SD) |
| Sleep disruption | |||||||||
| Hard time falling asleep | 42029% | 25727% | 16333% | Few X/wk | Daily/almost daily | 3.5 (1.7) | 3.7 (1.7) | 10.6 (6.8) | 12.1 (7.3) |
| Wake middle of night, back to sleep easily | 43630% | 28430% | 15231% | Few X/wk | Daily/almost dailye | 2.0 (1.6) | 2.2 (1.8) | 6.4 (5.8) | 7.7 (6.5) |
| Wake middle of night, awake >1 h | 62743% | 39642% | 23147% | Few X/wk | Few X/wke | 4.1 (1.6) | 4.3 (1.5) | 10.9 (6.2) | 12.7 (6.9)e |
| Wake middle of night, panic, anxious worried | 35725% | 22624% | 13127% | 1-2 X/mo | Few X/wk | 4.1 (1.6) | 4.1 (1.6) | 9.2 (6.1) | 9.9 (5.9) |
| Wake up very early in the morning | 36125% | 22023% | 14129% | Daily/almost daily | Daily/almost daily | 2.4 (1.7) | 2.5 (1.9) | 7.4 (6.1) | 8.4 (7.0) |
| Vasomotor symptoms and heart palpitations | |||||||||
| Hot flashes | 55739% | 27829% | 27957%f | 4-6 X/mo | Daily/almost dailye | 3.1 (1.6) | 3.7 (1.7)e | 7.6 (6.1) | 12.3 (7.6)e |
| Night/cold sweats | 62844% | 37740% | 25151%f | 4-6 X/mo | Daily/almost dailyf | 3.4 (1.8) | 3.7 (1.7) | 8.3 (6.5) | 11.2 (7.6)e |
| Heart palpitations | 42330% | 27027% | 15331% | 4-6 X/mo | Few X/wke | 3.6 (1.6) | 3.6 (1.8) | 8.0 (5.9) | 9.8 (7.1) |
| Mood changes | |||||||||
| Irritable (eg, short tempered, grumpy, impatient with others) | 80256% | 53757% | 26554% | 4-6 X/mo | Few X/wke | 4.0 (1.5) | 3.8 (1.5) | 10.0 (6.3) | 11.3 (6.6) |
| Feelings of anxiety (eg, more nervous) | 71350% | 45348% | 26053% | Few X/wk | Few X/wke | 4.2 (1.5) | 4.1 (1.5) | 11.8 (6.9) | 12.5 (6.6) |
| Easily overwhelmed, less able to cope | 60542% | 38341% | 22245% | Few X/wk | Few X/wkf | 4.2 (1.5) | 4.3 (1.5) | 11.8 (6.8) | 13.4 (7.0)f |
| Worry more | 44231% | 27930% | 16333% | Few X/wk | Few X/wk | 4.1 (1.5) | 3.4 (1.6) | 13.1 (6.5) | 13.4 (6.8) |
| Low feelings (eg, sad, blue, depressed, down, blah) | 59041% | 36038% | 23047%f | 4-6 X/mo | Few X/wk | 4.2 (1.6) | 4.1 (1.5) | 10.6 (6.8) | 11.3 (7.0) |
| Mood changes suddenly (mood swings) | 40628% | 26728% | 13928% | 4-6X/mo | Few X/wke | 4.3 (1.5) | 4.0 (1.6) | 10.7 (6.2) | 11.5 (6.8) |
| Experiencing panic attacks, feeling panicky | 25418% | 15717% | 9720% | 1-2X/mo | Few X/wk | 2.8 (1.1) | 2.7 (1.1) | 10.5 (6.7) | 10.8 (6.9) |
| Experience sudden anger, raging feelings, fly off the handle | 41329% | 27729% | 13628% | 1-2X/mo | Few X/wke | 1.0 (2.9) | 1.0 (2.6) | 10.1 (6.3) | 11.2 (6.6)e |
| Tearfulness, crying spells | 45932% | 29932% | 16033% | 1-2 X/mo | 4-6 X/moe | 3.5 (1.7) | 3.6 (1.7) | 7.7 (6.0) | 9.1 (6.7) |
| Feel like I can’t calm down on the inside, jumpy startle easily | 37226% | 23225% | 14029% | 4-6X/mo | Few X/wk | 4.4 (1.6) | 4.2 (1.6) | 11.2 (6.5) | 11.7 (7.0) |
| Headaches and sore breasts | |||||||||
| Tension headaches | 51036% | 34136% | 16934% | 4-6 X/mo | 4-6 X/mo | 3.4 (1.5) | 3.5 (1.5) | 7.3 (5.4) | 8.1 (5.6) |
| Migraine headaches | 26619% | 17819% | 8818% | 1-2X/mo | 1-2X/mo | 4.7 (1.4) | 4.4 (1.6) | 8.1 (5.0) | 8.1 (4.7) |
| Sore breasts | 65546% | 49052% | 16534%e | 1-2X/mo | 1-2X/mo | 2.7 (1.6) | 2.7 (1.7) | 4.5 (4.0) | 5.2 (5.3) |
| Brain fog and dizziness | |||||||||
| More forgetful | 90463% | 59660% | 33568%f | Few X/wk | Daily/almost dailye | 3.9 (1.6) | 4.2 (1.6) | 11.3 (6.6) | 13.4 (7.2)e |
| Have a harder time concentrating | 77854% | 49052% | 28859% | Few X/wk | Daily/almost dailye | 4.1 (1.5) | 4.4 (1.4) | 12.8 (6.7) | 14.8 (6.9)e |
| More difficulty making decisions, fuzzy thinking, confusion | 50535% | 31033% | 19540% | Few X/wk | Daily/almost dailye | 4.1 (1.5) | 4.5 (1.4) | 11.8 (6.5) | 14.5 (7.2)e |
| Feel dizzy | 31222% | 20221% | 11022% | 1-2X/mo | Few X/wke | 3.6 (1.7) | 3.9 (1.7) | 7.7 (5.9) | 9.8 (6.4) |
| Have vertigo (feel like I am on a boat) | 20414% | 12313% | 8117% | 1-2X/mo | 1-2X/mo | 3.9 (1.7) | 4.4 (1.6) | 7.2 (5.7) | 9.4 (6.5) |
| Feel lightheaded, like I might pass out | 28220% | 18319% | 9920% | 1-2X/mo | Few X/wk | 3.8 (1.7) | 4.1 (1.6) | 7.4 (5.3) | 9.8 (6.4)f |
LRS, late reproductive stage; MT, menopausal transition.
a
Chi square.
b
Mann-Whitney U.
c
t test.
d
t test.
e
P < 0.001.
f
P < 0.005.