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. 2021 Oct 27;95(22):e01424-21. doi: 10.1128/JVI.01424-21

FIG 1.

FIG 1

Fecal bacteria enhance the infectivity of CVB3 in vitro. Male C57BL/6 Pvr+/+ and Ifnar−/− mice were treated with an antibiotic cocktail for 10 days. (A) Bacterial load in the feces. Fecal pellets were collected from the antibiotic-treated and untreated group and plated to determine CFU per milligram of feces. Dashed line indicates the limit of detection; *, P < 0.05; Kolmogorov-Smirnov test. (B) CVB3 infectivity after exposure to PBS or feces from uninfected or antibiotic-treated mice (6 h at 37°C); n = 8 mice per group from 4 independent experiments. (C) CVB3 infectivity after exposure to selected Gram-positive and Gram-negative bacteria (6 h at 37°C). Data represent 2 to 6 independent experiments (n = 4 to 12). For all, bars represent mean ± SEM; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; one-way ANOVA.