FIG 8.

Sequence alignment of alphaherpesvirus gB homologue cytoplasmic tails. Species and their corresponding GenBank accession numbers (in parentheses) include HSV-1 (KT899744), HSV-2 (NC_001798), varicella-zoster virus (VZV) (X04370), saimiriine herpesvirus 1 (SaHV) (NC_014567), pseudorabies virus (PRV) (JF797218), bovine herpesvirus 1 (BHV1) (AJ004801), equine herpesvirus 1 (EHV1) (AY665713), feline herpesvirus 1 (FHV1) (S49775), canid herpesvirus 1 (CHV1) (NC_030117), and gallid herpesvirus 2/Marek’s disease virus (GHV2) (AF147806). The locations of helices h1a, h1b, h2, and h3 are indicated by the letter “h,” as defined previously by Cooper et al. (3). Regions resolved in the HSV-1 gB crystal structure (3) are underlined with a thick line. The region analyzed using electron spin resonance (ESR) is underlined with a thin line. Conserved residues at each position are highlighted in blue when identical or gray when similar. The position of HSV-1 gB-V880 is highlighted in yellow.