FIG 5.
Deletion of TAX1BP1 enhances the production of type I IFN and inflammatory cytokines in AMs following RSV infection. AMs from WT or TAX1BP1KO mice were either not infected (mock) (black triangles) or exposed to rHRSV-mCherry (RSV) (inverted black triangles) or UV-inactivated rHRSV-mCherry (UV-RSV) (white circles) at an MOI of 5 for 2 h. (A and B) The levels of production of IFN-α and IFN-β were measured at 24 h postinfection in the supernatants using a ProcartaPlex immunoassay. (C and D) The levels of production of IL-6 and TNF-α were measured at 24 h postinfection in supernatants using a MilliPlex Map immunoassay. Data are means ± SEM from two independent experiments. ***, P < 0.001.