TABLE 1.
Cellular proteins interacting with RSV Nmono identified by Y2H screeninga
| Gene | Gene ID | No. of hits | Functional annotation (GO biological process) |
|---|---|---|---|
| MAGEA11 | 4110 | 2/67 | Undetermined |
| TAX1BP1 | 8887 | 40/0 | Negative regulation of NF-κB transcription factor activity |
| Negative regulation of type I interferon production | |||
| Negative regulation of apoptotic process | |||
| TMCC3 | 57458 | 11/0 | Undetermined |
| IHO1 | 339834 | 5/0 | Synapsis |
| Regulation of homologous chromosome segregation | |||
| DNA recombination | |||
| Spermatogenesis | |||
| Oogenesis | |||
| Meiotic DNA double-strand break formation | |||
| BEND7 | 222389 | 0/4 | Undetermined |
| CCDC102B | 79839 | 4/0 | Undetermined |
a
The first and second columns correspond to the canonical gene names and gene identifiers of interacting cellular proteins, respectively. The third column shows the number of positive yeast colonies (hits) obtained for each cellular protein when screening the human spleen cDNA or the human ORFeome library. The fourth column provides information on the roles of the corresponding proteins using the Gene Ontology (GO) annotation (79, 80).