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. 2021 Oct 27;95(22):e01126-21. doi: 10.1128/JVI.01126-21

FIG 8.

FIG 8

Viral titers in the lungs, nasal turbinate, and brain of K18 hACE2 transgenic mice treated with 1212C2 or 1213H7 hMAbs and infected with rSARS-CoV-2 Venus and rSARS-CoV-2 mCherry SA. Six-to-8-week-old female K18 hACE2 transgenic mice (n = 3) injected (i.p.) with 25 mg/kg of an IgG isotype control, hMAb 1212C2, or hMAb 1213H7, and infected with 104 PFU of rSARS-CoV-2 Venus (A), rSARS-CoV-2 mCherry SA (B), or both rSARS-CoV-2 Venus and rSARS-CoV-2 mCherry SA (C). Viral titers in the lungs (top), nasal turbinate (middle) and brain (bottom) at 2 and 4 dpi were determined by plaque assay in Vero E6 cells. Bars indicate the mean and SD of lung virus titers. Dotted lines indicate the limit of detection. (D) Quantification of rSARS-CoV-2 Venus and rSARS-CoV-2 mCherry SA in the lungs (top), nasal turbinate (middle), and brain (bottom) from mice coinfected with both rSARS-CoV-2 Venus and rSARS-CoV-2 mCherry SA at 2 and 4 dpi. Statistical significance was determined by one-way ANOVA analysis on GraphPad Prism. ***, P < 0.001; ****, P < 0.0001.