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. 2021 Oct 27;41(43):9008–9030. doi: 10.1523/JNEUROSCI.2534-20.2021

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Copyright © 2021 Srinivasan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 1. — Shared and unique genetic architecture of genetic risk variants of addiction-associated traits. A, Pie chart of ANNOVAR-annotated (K. Wang et al., 2010) SNP function of addiction-associated trait lead and off-lead SNPs in LD R² > 0.8. Dark colors represent untranscribed/noncoding annotations; light colors represent transcribed/exonic annotations. SNP annotation labels are according to ANNOVAR using ENSEMBL build 85 gene annotations (see Materials and Methods). B, Pairwise LDSC genetic correlation (r_g) matrix of seven addiction-associated traits. Bold represents FDR-significant correlations. Gray represents nonsignificant correlations (FDR < 0.05). C, UpSet plot of nonoverlapping genomic loci shared or unique to each addiction-associated trait. Genomic loci are clustered and identified by shared GWAS-significant SNPs and genomic region overlap.