Figure 5.

Cell type-specific enrichment of substance use traits are conserved in mouse-human orthologous OCRs. A, Experimental design to map human orthologous regions from mouse ATAC-seq of bulk cortex (CTX), dorsal striatum (CPU), and NAc of cSNAIL nuclei of D1-cre, A2a-cre, PValb-2a-cre, and SST-cre mice. cSNAIL ATAC-seq experiments report enriched (+) nuclei populations. B, Stratified LD score regression finds enrichment of substance use and risky behavior traits for brain region- and cell type-specific ATAC-seq open chromatin profiles of mouse brain. Replication of enrichment is shown using INTACT-enriched OCRs from Mo et al. (2015) of cortical excitatory (EXC⁺), VIP interneuron (VIP⁺), and PV interneuron (PV⁺). Enrichments that are enriched at FDR ≤ 0.05 are plotted with black outlines and Bonferroni p value ≤ 0.05 with red outlines. FDR-adjusted p value was performed across all mouse-human ortholog GWAS enrichment across Figure 5.