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. 2021 Oct 12;11:725336. doi: 10.3389/fonc.2021.725336

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Copyright © 2021 Zhang, Ma, Long, Sun, Liu, Lin and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RUNX3 is a super-enhancer-associated gene only highly expressed in acute myeloid leukemia (AML) cells instead of in normal blood cells. (A) Experimental scheme to search for specific and highly expressed super-enhancer-associated genes in AML cells. (B) The Kaplan–Meier survival curves of RUNX3, TMEM50B, and TGOLN2 in The Cancer Genome Atlas (TCGA)-LAML database. (C) The RUNX3 mRNA expression of bone marrow cells from healthy volunteers (n = 5) or AML patients (n = 10). (D) Experimental scheme for panels (E, F). (E) qRT-PCR and (F) Western blot showing that RUNX3 expression was increased in murine leukemic cells from primary transplant mice compared with normal mouse bone marrow cells. ACTIN was used to show equal loading. Symbols represent an individual mouse.