Table 1.

Analysis of the Quality of Evidence: GRADE* Assessment

Outcome	Quality Assessment					GRADE Quality
	Studies (n)	Risk of Bias	Inconsistency	Indirectness	Imprecision
Histomorphological changes	3 randomized trials	seriousa	very seriousb	not serious	not serious	⊕○○○ Very low
	15 observational studies	very seriousc	very seriousb	not serious	seriousd	⊕○○○ Very low
Tissue factor expression	2 randomized trials	seriousa	very seriousb	not serious	not serious	⊕○○○ Very low
	12 observational studies	seriouse	very seriousb	not serious	seriousd	⊕○○○ Very low

^aAll studies were classified as some concerns. ^b the methodological heterogeneity between the included studies was considerably high; ^c 10 studies were classified as moderate and one as high risk of bias; ^d absence or extended confidence interval; ^e 10 studies were classified as moderate risk of bias.

^*GRADE Working Group grades of evidence.