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. 2021 Oct 27;53(3):576–580. doi: 10.1007/s11239-021-02589-y

Table 1.

Demographic, clinical, radiological and laboratory findings

Case 1 Case 2 Case 3 Case 4 Case 5
Age (years) 86 67 63 83 86
Gender M M M F F
Weight (Kg) 68 65 72 49 60
BMI  > 30
Hypertension + +
Diabetes + +
Heart failure + +
COPD + + +
Active cancer
Chronic renal failure +
Anticoagulant drug Rivaroxaban Edoxaban Apixaban Edoxaban Warfarin
Anticoagulant dose 15 mg day 60 mg day 5 mg BID 30 mg day
Plasma drug concentration ng/ml 68 (LloD: 25) 54 (LloD: 20) 48 (LloD: 25) 62 (LloD: 20)
Indication to anticoagulation AF Previous PE Previous PE AF AF
PE distribution Segmental Segmental Subsegmental Subsegmental Subsegmental
ARDS severity at admission Mild Severe Mild Severe Mild
PaO2/FIO2 ratio 187 93 178 88 190
PLT count x103 283 116 160 269 215
CRP mg/l (nv: <5) 70.5 82 33.2 321 27.3
D-dimer µg/ml (nv: 0.5) 3.99 18.4 7.2 0.27 1.7
LDH U/l (nv: <248) 234 786 214 447 358
INR 1.85 1.03 1.18 2.69 2.33
APTT (nv: < 1.2) 1.37 0.99 1.01 1.59 1.62
TTr (nv: <1.2) 1.10 1.3 1.60 1.2 0.9
Fibrinogen ml/dl (nv: < 200) 348 476 365 286 210
Creatinine mg/dl (nv: < 1.18) 1.28 1.09 0.86 0.74 0.6
eGFR (mL/min) 39.8 60.5 89 44.6 63.8

BMI body mass index, AF atrial fibrillation, PE pulmonary embolism, ARDS acute respiratory distress syndrome, PaO2 arterial partial pressure of oxygen, FIO2 fraction of inspired oxygen, PLT platelet, CRP C-reactive protein, LDH lactate dehydrogenase, INR international normalized ratio, APTT activated partial thromboplastin time, TTr thrombin time ratio, LloD lower limit of detection, eGFR estimated glomerular filtration rate