TABLE 2.

Comparison of significant differences (displayed as the p value) between the different experimental groups for (A) lesion volume, (B) brain edema, or (C) blood-brain barrier (BBB) breakdown 48 h after TBI by either histological and MRI-determined techniques.

Study groups	Histological				MRI				Method sensitivity assessment (number of p < 0.05 between study groups)
	Sham-operated	Mild TBI	Moderate TBI	Severe TBI	Sham-operated	Mild TBI	Moderate TBI	Severe TBI	Histological	MRI
Sham-operated									4	4
Mild TBI	NS				p < 0.05
Moderate TBI	p < 0.001	p < 0.05			p < 0.001	NS
Severe TBI	p < 0.001	p < 0.05	NS		p < 0.001	p < 0.05	NS
A
	Histological				MRI				Method sensitivity assessment (number of p < 0.05 between study groups)
	Sham-operated	Mild TBI	Moderate TBI	Severe. TBI	Sham-operated	Mild TBI	Moderate TBI	Severe TBI	Histological	MRI
Sham-operated									5	5
Mild TBI	p < 0.01				p < 0.01
Moderate TBI	p < 0.001	NS			p < 0.001	NS
Severe TBI	p < 0.001	p < 0.001	p < 0.05		p < 0.001	p < 0.01	p < 0.05
B
Study groups	Histological				MRI				Method sensitivity assessment (number of p < 0.05 between study groups)
	Sham-operated	Mild TBI	Moderate TBI	Severe TBI	Sham-operated	Mild TBI	Moderate TBI	Severe TBI	Histological	MRI
Sham-operated									6	5
Mild TBI	p < 0.01				p < 0.001
Moderate TBI	p < 0.001	p < 0.05			p < 0.001	p < 0.01
Severe TBI	p < 0.001	p < 0.001	p < 0.01		p < 0.001	p < 0.001	NS
C

NS: not significant.